1) before deactivating (if you already deactiveate it activate again) get somewhere indoors for example breezehome in whiterun.
2) Save game and close skyrim
3) Deactivate mod with nmm or with skyrim launcher (its not necessary to uninstall just deactiveate it)
4) Open skyrim and after bethesda logo select continue
5) After the game loads you wont be able to save again without CTD, so what you do is load the same game you loaded in step 4 (i mean the same game you are playing
6) After loading you will be able to save again....then hurry and do it!!!! from now on you can keep playing without skyrim live an without CTD
j'ai trouvé ça sur le nexus essaie ça peut etre que ca va marcher