C'est un bug courant, essaye de mettre à jour tes drivers :
"1. The game crashes at startup or during initialization of a new game
With a very high probability this problem can be solved by installing the latest graphics card drivers. We had this issue during the beta test phase multiple times and to our knowledge all these crashes were solved after installing the latest drivers."
Source : http://www.train-fever.com/forums/topic/most-common-issues/