Tottenham expect Gareth Bale to be fit, despite missing a few days training this week with a back problem.
Younes Kaboul returns after suspension and but fellow defenders Ledley King and Jonathan Woodgate are still out.
Manchester United welcome back Wayne Rooney and Nemanja Vidic after the pair sat out the FA Cup win over Liverpool.
Goalkeeper Edwin van der Sar returned to training on Friday after a virus and is expected to be fit enough to replace Tomasz Kuszczak.
Tottenham
Injured: Huddlestone (ankle), King (groin), O'Hara (back), Woodgate (fitness)
Man Utd
Doubtful: Scholes (groin), Van der Sar (illness)
Injured/unavailable: Hargreaves (hamstring), O'Shea (calf), Park (international duty), Valencia (ankle)